The effects of different trench parameters on the crosstalk and the mode area in the trench-assisted multi-core fiber are investigated systematically. Simulations suggest that low crosstalk and/or large mode area can be achieved by adjusting the trench parameters. Furthermore, the effects of different trench parameters on the dispersion characteristic are discussed, and the dispersion characteristics of the structures are verified experimentally. These characteristics suggest that the large-mode-area low-crosstalk trench-assisted multi-core fiber can be an important potential candidate for practical applications.