Quartz sand with two kinds of particle sizes was used as raw materials and the lime milk and waste paper pulp were used as binders to prepare silica brick after sintering at 1 430 ℃. The effects of multi-mineralizer and holding time on the phase composition, microstructure and main physical properties of silica brick were studied. The results show that the fired specimen is composed of tridymite, cristobalite, and a small content of residual quartz after sintering at 1 430 ℃ for 10 h. With the addition of iron scale powder-CaO-MnO2-SiC or iron scale powder-CaO-MnO2-TiO2, the typical aggregate-matrix refractory structure in silica brick disappears, as well as the homogenization effect appears. The fired specimen has good comprehensive properties after sintering at 1 430 ℃ for 10 h when the mineralizer is iron scale powder-CaO-MnO2-TiO2, and the bulk density, apparent porosity, and cold crushing strength are (1.93±0.01) g·cm-3, (14.9±0.1)%, and (55.05±0.64) MPa, respectively. Based on the optimal mineralizer composition and firing system, when the holding time is extended to 15 or 20 h, the residual quartz content in the material decreases, and tridymite content increases, which make that the volume expansion effect is enhanced, and the physical properties of the material are damaged.