A facile route to prepare nanoporous antireflective coating (ARC) composed of organic/inorganic latex particles of poly(2,2,3,3-terafluoropropyl methacrylate -co-γ-methacryloxypropyltrimethoxysilane [P(TFPMA-co-TMSPMA)] on glass substrates by spin-casting binary latexes of P(TFPMA-co-TMSPMA)/polystyrene (PS), and then selectively removing the PS particles with cyclohexane is reported. The effects of concentration of binary latexes, rotation speed, as well as the size of the latex particles on the antireflective performance are studied. Nanoparticle coatings which exhibited satisfying antireflective performance in the wavelength range of 400~1100 nm and with the highest transmittance above 99.1% are prepared with thickness in 109~208 nm and refractive indices about 1.22~1.25. It is also found that the surface roughness and the optical transmittance of the nanoporous coatings are related with the size of the latex particles used for the ARC. Nanoparticle coatings with reduced surface roughness can be prepared with latexes of smaller particle size.