An endoscope scanning fiber probe was designed to perform two-dimensional (2D) scanning for optical coherence tomography based on the PZT. Two piezoelectric ceramic and a thin conductive substrate were used to drive the optical fiber probe. The probe used the cantilever resonance of optical fiber cantilever, imposed the mixing signals which closed to the resonant frequency of optical fiber on the piezoelectric ceramic, and also stimulated two orthogonal directions vibration of fiber cantilever to achieve two-dimensional scanning. Theoretical model was established and took the finite element simulation analysis was carried out. A practical model was made to carry out experiments and otain the scan pattern. The experimental results realize the optical fiber cantilever two dimensional scanning, and the scanning scope reaches (500×500)μm, adjusting drive signal amplitude can change the scanning range. The theoretical analysis and the simulation was consistent, and verified the feasibility of the scheme.