Fully tempered vacuum glass (FTVG) is a new type of high-end architectural glass material that has excellent thermal insulation, sound insulation, safety performance and other advantages, which are highly valued in modern architecture. As an important component of FTVG, the parameters of the pillars have a significant influence on their equivalent stress and deformation properties. Numerical analysis was conducted on the effects of spherical, cylindrical and annular pillars with different spacing and arrangement on the equivalent stress and deformation of FTVG. The research results show that regardless of the shape or arrangement of the pillars, the maximum equivalent stress and deformation are positively correlated with the spacing. Under other conditions being equal, the equivalent stress and deformation of FTVG with circular pillar and equilateral triangle arrangement are the least. This study has obtained reasonable pillar spacing for different shapes and arrangements through simulation results, providing a theoretical basis for the manufacture of FTVG.