In order to solve the problem that single median filtering and gaussian filtering algorithm is not effective in suppressing impulse noise and poisson noise simultaneously in low illumination image, and the edge detail protection is insufficient, an open and close mix-median-gaussian (OCMMG) filtering algorithm based on field programmable gate array (FPGA) was proposed. Firstly, the minimum four-direction difference was used to detect the anomaly degree of each pixel point, the weight was allocated according to the threshold of pulse noise discrimination, and the first step was filtering. Then, the four-direction edge detection algorithm was used to extract image edges, and the second step was filtered according to the set edge confidence characterization value. Finally, the images collected by electron bombarded active pixel sensor (EBAPS) under the condition of 1×10^?3 lx illumination were processed by FPGA in real time. The experimental results show that the FPGA processing results are consistent with the software simulation processing results. Compared with the median filtering and gaussian filtering algorithm, the peak signal-to-noise ratio (PSNR) of the algorithm is improved by 3.23% and 16.34%, the structural similarity is improved by 14.66% and 33.86%, and the edge retention index is improved by 0.49% and 4.21%, respectively, which can effectively remove the mixed noise of EBAPS image and meet the real-time requirements.