Pipeline transportation safety is critical for guaranteeing the national economy and people's life, and pipeline leakage monitoring is significant for achieving pipeline transportation safety. This paper proposes a multi-dimensional spatial data fusion algorithm for pipeline leakage monitoring based on a distributed optical fiber vibration sensing (DVS) system. The optical fiber sensing cable was fixed on the side of a pipeline, and the pipeline leakage signals were picked up by the DVS system. These pipeline leakage signals were averaged in the space-time domain based on the time window and spatial resolution, respectively. Finally, a suitable threshold was set to complete the pipeline leakage monitoring alarm. Single-point and multipoint pipeline leakages are tested in the experiment. The signal-to-noise ratio of the single-point pipeline leakage signal increases by 4.5 dB, maximum single-point pipeline leakage alarm rate increases by 19.53%, and maximum multipoint pipeline leakage alarm rate increases by 2.29%. Notably, real-time monitoring and alarms for pipeline leakage under a pressure of 0.2 MPa are achieved.