Journal of Innovative Optical Health Sciences, Volume. 8, Issue 1, 1540005(2015)

Photodynamic therapy of oral leukoplakia and oral lichen planus using methylene blue: A pilot study

[in Chinese]1... [in Chinese]2, [in Chinese]3, [in Chinese]4, [in Chinese]2 and [in Chinese]3,* |Show fewer author(s)
Author Affiliations
  • 1Department of Medical PhysicsAnna University, Chennai-600025, India
  • 2Department of Oral Medicine and Radiology Meenakshi Ammal Dental College Maduravoyal, Chennai-600095, India
  • 3Department of Medical Physics Anna University, Chennai-600025, India
  • 4Department of Oral Medicine and Radiology Sathyabama University Dental College, Chennai-600119, India
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    Premalignant lesions like oral lichen planus (OLP), oral leukoplakia (OL) has a fair probability of transforming into malignancy and they are perverse toward conventional therapies. Photodynamic therapy (PDT) has been considered as an alternative/complimentary therapeutic modality for the management of premalignant lesions. In this study, methylene blue-mediated photodynamic therapy (MB-PDT) was used as a possible alternative method for the treatment of OLP and OL. A total of 15 OLP lesions and 13 OL lesions were enrolled in the study. The patients were irradiated using metal halide lamp filtered at 630 ± 10 nm, with a light exposure dose of 120 J/cm2 per sitting. For the OLP lesions, MB-PDT was performed once a week for four weeks and for the OL lesions, MB-PDT was performed twice a week for three weeks. Lesions were evaluated pre- and post- and at follow-up sessions by changes in sign and symptom scores, and size of lesions. We have observed a 53.3% of complete reduction in the treated OLP lesions and their decrease in size, sign and symptom score after treatment and at follow-up session was statistically significant. We have also observed complete response for one OL lesion of the 13 treated lesions. The result indicates that MB-PDT is an effective modality in management of OLP and OL. Among the two types of premalignancies treated with MB-PDT, OLP lesions responded much better than that of OL.

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    [in Chinese], [in Chinese], [in Chinese], [in Chinese], [in Chinese], [in Chinese]. Photodynamic therapy of oral leukoplakia and oral lichen planus using methylene blue: A pilot study[J]. Journal of Innovative Optical Health Sciences, 2015, 8(1): 1540005

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    Paper Information

    Received: Jan. 2, 2014

    Accepted: Apr. 20, 2014

    Published Online: Jan. 10, 2019

    The Author Email: (sganesan@annauniv.edu)

    DOI:10.1142/s1793545815400052

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