Chinese Journal of Lasers, Volume. 41, Issue 3, 304001(2014)
Dynamic Characteristics of Vascular Morphology after 1064 nm Laser Exposure
Recently, laser therapy has been widely used for treating portwine stain (PWS) and other vascular lesions. However, the mechanism of the vascular injury during the treatment process is still not clear. In this paper, a hamster dorsal window chamber model is constructed to investigate the dynamic change of the vessel during pulsed laser treatment. A CCD camera and microscope are used to capture the dynamic variation of microvessels after 1064 nm laser pulse exposures. Experimental results show that the vessel continues expansion with the increasing of the radiant exposure, and vasoconstriction appears when the energy accumulates to a certain value with a single laser pulse. After multiple laser pulse irradiation, vessel expansion, blood coagulation and vasoconstriction are observed. These results may provide useful feedback for the treatment of PWS by near-infrared long wave laser.
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Wu Wenjuan, Li Dong, Xing Linzhuang, Chen Bin, Wang Guoxiang. Dynamic Characteristics of Vascular Morphology after 1064 nm Laser Exposure[J]. Chinese Journal of Lasers, 2014, 41(3): 304001
Category: biomedical photonics and laser medicine
Received: Aug. 2, 2013
Accepted: --
Published Online: Mar. 3, 2014
The Author Email: Wenjuan Wu (wuwenjuan@stu.xjtu.edu.cn)