At first, a finite element model of the radial connection structure of aircraft cabin based on the solid element bolt modeling is established. And then, a structural quality optimization design process considering the parameter sensitivity analysis step is constructed. At last, the optimal design of the aircraft radial connection structure with different cabin diameters and cabin materials is carried out, and the optimal design scheme is obtained, and the advantages and disadvantages of the performance of different cabin materials are compared and analyzed. The research results can shorten the design cycle and save the cost for the preliminary design of radial connection structure without sample strength.