To obtain high-quality images during the operation of the Tianwen-1 payload high-resolution camera， the imaging parameter settings were investigated. Combined with the results of laboratory calibration experiments， the default parameters of the camera in orbit and the imaging parameters under different ground reflectivities and sun altitudes were determined. First， the radiance of each spectral segment at the entrance pupil of the camera was calculated based on the atmospheric radiation transfer model. Then， the output charge value of the CCD detector was obtained by applying the photoelectric conversion model. Furthermore， the imaging parameters of the camera were obtained， and were found to meet the requirement of SNR > 100. Finally， spectral calibration and radiometric calibration were conducted under laboratory conditions， and the calibration error was analyzed. The experimental results indicate that the video response of the high-resolution camera is linear， relationship between the gray value and imaging parameter is linear， correlation coefficients of linear fitting are all above 0.999， non-uniformity of each spectral segment is less than 1%， and SNR is no less than 100 under typical lighting conditions. The relative radiometric calibration uncertainty is better than 3%， and the absolute radiometric calibration uncertainty is better than 7%. The results of the theoretical calculation and calibration are found to be basically consistent. Thus， the imaging parameters are designed reasonably， and the calibration results meet the system requirements.