The effective detection of high repetition rate interference lasers depends on the accurate performance of laser seekers. Therefore, we use computational analysis to investigate the laser-seeker detection performance and false-alarm probability. By applying this method, we reach the conclusions that when the threshold-to-noise ratio T_NR=3.5, the approximate false-alarm probability P_f=0.02%; when T_NR=3.5 and the power density of the detected signal at the seeker entrance is 1.9 times the seeker-detector threshold, the approximate detection probability P_p=99.92%. Considering such detection probability, we study the high repetition rate interference laser to obtain the relationship among the laser-seeker detection probability P_p,parameters of the high-frequency interference laser (average power P₁, pulse-transmission frequency f, and pulse width τ), laser-seeker parameters (detector threshold P_th and threshold-to-noise ratio T_NR),and action distance R. During this process, we use MATLAB for simulation analysis in combination with the application background.