In order to make comprehensive use of solid waste from Bayan Obo Mine, the effects of different raw material ratios on the preparation of glass-ceramics were studied by one-step sintering method with fluorite tailings of Bayan Obo and blast-furnace slag of Baotou Steel as main raw materials. DSC, XRD, SEM, universal testing machine and multi-channel γ spectrometer were used to characterize and analyze the effects of different raw material ratios on the preparation of glass-ceramics. The results show that the main crystalline phases of glass-ceramics are clinopyroxene, diopside and tridymite when the ratio of raw materials is different. With the increase of the mass ratio of fluorite tailings to blast-furnace slag, the color of glass-ceramics gradually darkens, and the flexural strength increases first and then decreases, then increases and decreases. When the mass ratio of fluorite tailings to blast-furnace slag is 5∶5, the flexural strength of glass-ceramics is the highest, reaching 76.85 MPa, and the main crystalline phase is clinopyroxene and diopside, with uniform grain size and regular arrangement. When the mass ratio of fluorite tailings to blast furnace slag is 2∶8, the glass-ceramics product meet the class B decoration material standard, and when the mass ratio is 3∶7, 5∶5, 6∶4, it meets the class C decoration material standard.