Spectroscopy and Spectral Analysis, Volume. 33, Issue 10, 2731(2013)
Synthesis and Photodynamic Anticancer Activity of Silicon Phthalocyanine Axially Modified by Nucleoside Derivatives
A new axially modified silicon phthalocyanine, di [5′-(2′, 3 ′-O-isopropyl)-5-methyl cytidineoxy] silicon phthalocyanine (SiPcG), was prepared and characterized by 1H NMR and HRMS. This compound is essentially nonaggregated in N,N-dimethyformamide and 1% cremophor EL aqueous solution. It shows a Q-band at 676 nm and fluorescence emission at 685 nm in DMF, and exhibits a Q-band at 679 nm and fluorescence emission at 689 nm in 1% cremophor EL aqueous solution. The SiPcG shows a high photodynamic activity against human hepatoma cells HepG2 with an IC50 value down to 7.8×10-8mol·L-1. Fluorescence confocal microscopy study indicated that the SiPcG locates preferentially in the mitochondria of cells. The research results show that the SiPcG is highly potential as a new anti-cancer photosensitizer.
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SHEN Xiao-min, ZHENG Bi-yuan, ZHANG Han-hui, HUANG Jian-dong. Synthesis and Photodynamic Anticancer Activity of Silicon Phthalocyanine Axially Modified by Nucleoside Derivatives[J]. Spectroscopy and Spectral Analysis, 2013, 33(10): 2731
Received: Jan. 21, 2013
Accepted: --
Published Online: Oct. 23, 2013
The Author Email: Xiao-min SHEN (shxm830315@163.com)