In order to solve the problems of long test cycle, high research and development cost and unstable product quality in the research and development to production stage of optical fiber products in the field of optical communication, based on the six Sigma quality management method, the invention problem solving theory(TRIZ)-design of experiments(DOE)-process capability Cpk model was established and applied to the development of anti-bending fiber G.657-B3. This model is beneficial to carry out efficient test design and test cost control, determine the best combination of refractive index profile parameters of G.657.B3 fiber, and apply to mass production. The experimental results show that at the wavelength of 1550 nm and 1625 nm, the typical loss of macro bending is 0.063 dB and 0.165 dB, respectively, when the bending radius is 5 mm and one circle is made, and the macro bending performance of the fiber is good.