This study addresses the blasting demolition of an 18-story oval frame-core tube structure. Systematic analysis revealed that the structure's small height-width ratio and long span contribute to potential instability and collapse, with uneven stress distribution due to irregular shear wall placement within the core tube. To mitigate these challenges, delayed blasting and auxiliary weakening techniques were employed. The approach included pre-treatments such as splitting and cutting to transform the cylindrical structure into a wall-like form, reducing deviation during collapse. The building was divided into four blasting zones with increasing delay times, particularly extending the delay for the last two zones by 1 second to ensure sequential support point failure and prevent incomplete collapse. Additionally, the upper and lower double-incision folding blasting method was utilized to control vibration upon ground impact and enhance overall dissociation. The demolition process, lasting approximately 5 seconds, resulted in the building collapsing primarily along the designed direction with minimal backseat movement and evident structural failures. The sequential floor folding and concentrated pile blasting demonstrated effective demolition.