Clobetasol propionate (CP) is a kind of glucocorticoid, which can be used to treat eczema, psoriasis and other skin diseases. Long-term and frequent use of CP-contained skin care products by infants and young children may lead to serious health hazards. CP is a prohibited ingredient in cosmetics, and it is necessary to develop a rapid and simple method to detect the banned hormone CP in skin care products. In this work, there is a halogen exchange reaction between orange luminescent all-inorganic perovskite quantum dots (CsPbBr1.5I1.5 QDs) and CP, and the fluorescence peaks occur blue shift. There is an excellent linear relationship between the shift wavelength of CsPbBr1.5I1.5 QDs emission peak and the concentration of CP, which realizes the rapid analysis of the content of CP in infant skin care products. The detection limit is 0.2 mmol·L-1, and the detection time is 10 min. A luminescent color card for CP detection in infant skin care products was made, which could be used to quickly, accurately, and simply evaluate CP content in infant skin care products.