Laser & Optoelectronics Progress, Volume. 61, Issue 9, 0923001(2024)

Design and Implementation of Real-Time Fluorescence Triple Correlation Spectroscopy Correlator Based on FPGA

Yanan Sun1, Ping Cai1、*, Weida Wang1, Xinwei Lu2, Chaoqing Dong2, and Jicun Ren2
Author Affiliations
  • 1Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • 2School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
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    To meet the requirements of multichannel fluorescence correlation spectroscopy with a wide dynamic range, a digital correlator based on field programmable gate array (FPGA) technology was designed and implemented. The hardware structure was designed and implemented using a register-level hardware description language. Based on the characteristics of photon pulse counting signals, the multi-sampling-time correlation and time-division multiplexing methods were used to calculate the correlation function, which substantially improved computing efficiency and optimized hardware resource utilization. The time-division multiplexing of cross correlation was extended to triple correlation, and the corresponding method was extended to adapt triple correlation. Ultimately, a real-time computing triple correlator based on FPGA was realized. The calculation method of symmetric normalization ensured the accuracy of the correlation function. The designed photon correlator was implemented based on a single Xilinx Zynq-7100 FPGA chip, which performed various functions, including the real-time correlation of three channels auto-correlation, three channels cross-correlation, and one channel triple correlation, with the time resolution of 40 ns and dynamic range of 1.57 × 107.

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    Yanan Sun, Ping Cai, Weida Wang, Xinwei Lu, Chaoqing Dong, Jicun Ren. Design and Implementation of Real-Time Fluorescence Triple Correlation Spectroscopy Correlator Based on FPGA[J]. Laser & Optoelectronics Progress, 2024, 61(9): 0923001

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    Paper Information

    Category: Optical Devices

    Received: Dec. 2, 2022

    Accepted: Dec. 24, 2022

    Published Online: May. 10, 2024

    The Author Email: Cai Ping (pcai@sjtu.edu.cn)

    DOI:10.3788/LOP223230

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