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Journal of Innovative Optical Health Sciences, Volume. 11, Issue 4, 1850018(2018)

Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

Yingyi Liu1, Siyi Hu2, Yueshu Feng3, Peng Zou4, Yue Wang4, Pei Qin4, Jie Yue4, Yaotian Liang4, Hui Wang5, and Liwei Liu6、*
Author Affiliations
  • 1Bohai Ship-building Vocational College, Huludao 125000, Liaoning, P. R. China
  • 2CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China
  • 3Jilin Weather Modification O±ce, Changchun 130062, Jilin, P. R. China
  • 4School of Science, Changchun University of Science and Technology, Changchun 130022, Jilin, P. R. China
  • 5Department of Ultrasound, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin, P. R. China
  • 6Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China
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    In this paper, we prepared the nanoparticle drug carrier system between nanoparticles — chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.

    Keywords
    Epigallocatechin-3-O-gallateinhibits tumornanoparticles
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    Yingyi Liu, Siyi Hu, Yueshu Feng, Peng Zou, Yue Wang, Pei Qin, Jie Yue, Yaotian Liang, Hui Wang, Liwei Liu. Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells[J]. Journal of Innovative Optical Health Sciences, 2018, 11(4): 1850018

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    Paper Information

    Received: Sep. 3, 2017

    Accepted: Apr. 3, 2018

    Published Online: Oct. 6, 2018

    The Author Email: Liu Liwei (liulw@szu.edu.cn)

    DOI:10.1142/s1793545818500189

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology