Dielectric metallic hollow waveguides have attracted wide attention as flexible gas absorption cells for spectroscopic gas sensing. Advantages of the hollow waveguide include low loss, stable coupling with the optical transmission system, strong anti-interference ability, and a small sample volume. A spectroscopic gas sensing system was established using the Fourier infrared spectrometer (FTIR) and the flexible waveguide absorption cell. Durability characteristics of the waveguides were studied experimentally for various waveguides in alkaline gas, acidic gas, and volatile organic solvents. Loss properties of the hollow waveguide were measured before and after the corrosive treatment. Damage was evaluated and the degradation mechanism was discussed. The applicable sensing bands and corrosive environments of various commonly used waveguides were summarized systematically. Helpful choices are provided in the design and production for engineering application of the waveguide as the absorption cell.