Titanium doped sapphire (Ti:Al2O3) laser crystals are widely used in the tunable laser, high power laser and ultra-fast laser because of their characteristics of high hardness, high thermal conductivity, broadband absorption and broadband emission. In recent years, the growth technology, theoretical analysis and device-based application of Ti:Al2O3 crystals have been greatly developed, and the research on Ti:Al2O3 crystals has been more and more intensive and extensive. The research and application of Ti:Al2O3 crystal materials are reviewed.