The mineral admixture resources of fly ash-based concrete in southwest China are scarce, and it is urgent to develop alternative materials. In this paper, the effects of four kinds of igneous rock mineral materials on the working performance, mechanical properties and durability of concrete were studied, and the cracking risk of concrete was evaluated. The results show that the compressive strength and chloride ion penetration resistance of hardened concrete meet the standard requirements after replacing fly ash with igneous rock mineral materials by equal quality. The dosage of water reducing agent, early compressive strength, electric flux and shrinkage rate are higher than those of fly ash concrete. The performance of hardened concrete mixed with tuff micropowder is basically the same as that of fly ash concrete. Basalt micropowder concrete has the largest demand for water reducing agent and the lowest compressive strength. The crack resistance of concrete mixed with igneous rock mineral materials is reduced. The cracking risk of concrete mixed with tuff micropowder and fly ash is low level, and the cracking risk of concrete mixed with andesite micropowder, basalt micropowder and rhyolite micropowder is medium-low level. Among the four kinds of igneous rock mineral materials, tuff micropowder concrete has the best performance and can replace fly ash into concrete.