Infrared air-to-air missiles are the most effective close combat destructive weapons, but their working mechanisms are complex, jamming environment are variable, so the simulation missiles are hard to match the real. To simplify the simulation process and improve the accuracy of the simulation results, start from missiles functional simulation and abandon the complicated physics simulation, only concentrate on identification, guidance, control and motion process. Firstly, missile mathematical models were established based on the three degrees of freedom to simplify missiles motion equations. Secondly, the anti-interference method was classified, analysed different anti-interference mechanisms between the seeker entered into anti-interference state and couldn′t enter into. Lastly, the simulation platform to the missile models, bait models and aircraft models as the core were established and miss distance, missile trajectories, anti-interference probability were used as evaluation criteria of simulation results. The simulation results show, the simulation infrared air-to-air missile models are simple and easy to implement and anti-interference results are close to the real missiles, also can meet the requirements of combat assessment.