Chinese Physics B, Volume. 29, Issue 10, (2020)
The theory of helix-based RNA folding kinetics and its application
RNAs carry out diverse biological functions, partly because different conformations of the same RNA sequence can play different roles in cellular activities. To fully understand the biological functions of RNAs requires a conceptual framework to investigate the folding kinetics of RNA molecules, instead of native structures alone. Over the past several decades, many experimental and theoretical methods have been developed to address RNA folding. The helix-based RNA folding theory is the one which uses helices as building blocks, to calculate folding kinetics of secondary structures with pseudoknots of long RNA in two different folding scenarios. Here, we will briefly review the helix-based RNA folding theory and its application in exploring regulation mechanisms of several riboswitches and self-cleavage activities of the hepatitis delta virus (HDV) ribozyme.
Get Citation
Copy Citation Text
Sha Gong, Taigang Liu, Yanli Wang, Wenbing Zhang. The theory of helix-based RNA folding kinetics and its application[J]. Chinese Physics B, 2020, 29(10):
Received: Jun. 29, 2020
Accepted: --
Published Online: Apr. 21, 2021
The Author Email: Zhang Wenbing (wbzhang@whu.edu.cn)