The instrument sharing platform is a characteristic platform established by universities and research institutes, which integrates large-scale instrument sharing, scientific research tasks, instrument function and method development. The safe operation of the platform is the key to management. This article analyzes the operating status and main safety hazards of the instrument sharing platform from the perspective of safety, and initially explores management from the aspects of platform supervision and control management, instrument sharing management, laboratory safety management, chemical reagent management, safety education management and emergency management. The model aims to establish a perfect safety guarantee system for the instrument sharing management platform, and to provide new ideas for the management of instrument sharing platform.