In this paper, a 64 mm×64 mm matrix polymer solar cell (PSC) was fabricated by air-brush spray deposition. Although the open-circuit voltage (Voc) and the fill factor (FF) both need to be improved, the efficiency of matrix PSCs still reaches about 1.82%, and especially the current density achieves nearly 20 mA/cm². The results verify that air-brush spray deposition is a suitable method to prepare large area PSC devices, and the process we use in this paper can be easily transplanted to roll-to-roll production.