The application of luminescent nanomaterials combined with organic dyes in multi-sensing is studied in this paper. The luminescent nanomaterial CdSe/ZnS and the organic dye Pt(Ⅱ)meso-Tetra(pentafluorophenyl)porphine are embedded in polyurethane hydrogel D4, so a solid film is obtained through hydrolysis and condensation to achieve simultaneous detection of oxygen concentration and temperature. Among them, CdSe/ZnS luminescent nanomaterials with an emission peak at 524 nm are used to provide temperature sensing, and oxygen sensing is based on the dynamic quenching of Pt(Ⅱ)meso-Tetra(pentafluorophenyl)porphine with an emission peak at 650 nm. The prepared thin film has good optical stability and is excited by 405 nm violet light to obtain a spectrum in which the two emission peaks do not overlap with each other. The experimental results show that the sensing membrane can be well applied to the oxygen and temperature dual sensing systems. Under the oxygen concentration (0~30%) and temperature (15~67℃), the sensitivity coefficient of oxygen sensor is 9.69×10^-4 and the sensing coefficient of temperature is -0.003 5 (with an error of±0.000 2). This technology provides a possibility for new portable multi-sensors.