It is an interesting topic to improve the photocatalytic H2 evolution activities of catalysts. In this parper, CdS nanospheres on titanium meshes have been synthesized by a simple hydrothermal method. The composition, microstructure and morphology of samples were investigated using X-ray diffractometer (XRD), scan electron microscopy (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). And the photoelectrochemical properties and photocatalytic properties under visible light were studied. The results show that, each CdS nanosphere on titanium meshes is self-assembled with nanorods. Then, the samples were used as photoelectrochemical photoanodes and photocatalytic water-splitting processes, the sample with a Cd/S amount of substance ratio of 1∶1 (CdS-1) has a good photoelectric response, and has a maximal photocurrent of ~140 μA. At the same time, the results show that the sample has a good H2 evolution activity with the rate of 212.6 μmol·h-1·cm-2 and recycling convenient, reusable, which can be an ideal photocatalyst.