There are significant differences between biological alumina ceramic and polymer in mechanical properties, chemical properties and thermal properties, so the performance differences set a challenge to achieve the high strength joint between them. A thin titanium film is deposited on the biological alumina ceramic, laser transimission joining experiments between Ti coated bio-ceramic and polyethylene terephthalate (PET) are conducted by using a near infrared continuous wave (CW) diode laser, which solves the connection problems of bio-ceramics and polymers. The joined samples are tested by lap-shear test to determine the joint strength, and examined by optical microscopy to obtain the joint morphology and joint width. The effects of the laser power and the scanning speed on joint strength and joint width in laser transmission joining process are also investigated. The parameters window for laser transmission joining process is obtained via the single factor process analysis, and a reasonable range of processing parameters is provided for laser transmission joining.