A parameterized hole placement design method for medium-depth holes was proposed to solve the problems of large subjectivity of manual interaction, cumbersome and complex adjustment of hole placement and difficulty in ensuring the uniformity of hole bottom distance. Firstly, a mathematical model in underground mines was constructed using the parameterized hole layout idea combined with the blasting boundary space constraints and blasting parameter requirements. Furthermore, the mathematical model was solved using the operation research method to get the optimal hole design on a digital mining software platform. Finally, the model was used in an underground mine. The result shows that the standard deviations of the bottom distance for the manually laid holes are 0.08 m, 0.10 m, 0.07 m and 0.07 m, respectively, while those for the automatically laid holes with the parameterized method are 0.02 m, 0.03 m, 0.02 m and 0.02 m, respectively. The hole laying time is shortened from 4 hours to 5 min. The proposed method significantly reduces the workload of the designing technicians and maximizes the guarantee of inter-hole laying between holes. It maximizes the uniformity of the bottom distance and avoids the randomness and error-prone nature.