The locating of remote (over 500 m away from the monitoring station) laser spot center in the actual environment with weak laser intensity and laser path interference was studied.Firstly, image preprocessing was used to suppress camera noise.Secondly, the laser spot intensity distribution model was constructed to segment the laser spot.Then, morphological corrosion operation was used to suppress the false segmentation, and the processed segmentation image was meshed.By calculating the credibility of the grid and the coordinate of the center of the grid, the combination of the coordinate of the center of the grid was completed to locate the center of the first-order spot.Finally, in combination with prior knowledge and the score of center possibility, the center point search was adjusted to complete the secondary positioning, and the laser spot center was obtained.In verification under actual scenario, the proposed algorithm can perfectly locate the center of the remote laser spot in an environment with weak laser intensity and obvious optical path interference.