This paper investigates a spectral optimization simulation method based on multi-channel light-emitting diodes (LEDs). According to the principle of linear superposition of spectra, each color LED spectrum is imported into the program, and the model is programmed to output the best combination of color rendering index, luminous efficacy, and color tolerance under the specified color temperature conditions to guide the dimming and color adjustment applications of multi-channel LED lighting products. The experimental results show that the warm white LEDs mixed with RGB (Red, Green, Blue) light have the best combination of photometric chromaticity parameters in the color temperature range of 3000-5000 K, and the cool white LEDs mixed with RGB light have the best effect in the range of 5000-8000 K. The visual efficacy and non-visual efficacy of each optimal spectral combination solution are discussed, and the optimal solution of the spectrum is experimentally verified.