In order to investigate the effects of steel fiber, polyvinyl alcohol (PVA) fiber and mineral powder contnet on permeability resistance of steel-PVA hybrid fiber high performance concrete (HFHPC). The orthogonal experiment was designed to conduct the permeability resistance test of steel-PVA HFHPC, and the test results were analyzed through range analysis, variance analysis and regression analysis. The results show that the influence degree on the impermeability of HFHPC is steel fiber, mineral powder and PVA fiber from high to low. In the range of test level, the optimal horizontal combination of impermeability of concrete specimens is as follows: steel fiber volume fraction of 1.0%, PVA fiber volume fraction of 0.7% and slag powder mass replacement rate 20%. When the steel fiber volume fraction exceeds 1.0%, the impermeability of HFHPC decreases slightly, but it is still higher than that of standard plain concrete. Finally, multiple regression analysis is used to establish the prediction model of HFHPC permeability and steel fiber, PVA fiber and mineral powder.