In view of the defects of high energy consumption and pollution in the traditional optical fiber preform manufacturing process, this paper proposes a green and environmentally friendly cladding manufacturing process with quartz sand as raw material. Through the selection and analysis of quartz sand raw materials, it is shown that natural quartz sand is suitable for the manufacture of optical fiber preforms. Through the research on the key control points of the natural quartz sand preform making process, the quartz sand is filled into the prefabricated assembly consisting of a core rod and a thin-walled quartz tube. A large-size G.652.D optical fiber preform with an average outer diameter of 155 mm is then successfully prepared by high-temperature melting and shrinking. After fiber drawing and testing, the optical parameters can meet the low water peak optical fiber standard. There is no exhaust gas emission in the process raw material of quartz sand can be completely converted, which is more low-carbon and environmentally friendly than traditional optical fiber preform manufacturing process.