Spectroscopy and Spectral Analysis, Volume. 33, Issue 10, 2736(2013)
Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan
The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging (MRI) contrast agent was synthesized through tetra(4-carboxyphenyl) Mn(Ⅱ)-porphyrin (Mn-TCPP) modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemical structures of the products were characterized with Fourier transform infrared spectra (FTIR), UV-Vis spectra, mass spectrum (MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). The results showed that Mn-TCPP was successfully linked to CS20 by an amide function. The relaxation properties in vitro of the functional complex Mn-TCPP-CS20 as the potential MRI contrast agent were preliminarily studied. It was found that the longitudinal relaxivity (r1) of the synthesized Mn-TCPP-CS20 (6.11 mmol-1·L·s-1) was higher than that of the commercial contrast agent Gd-DTPA (r1=3.59 mmol-1·L·s-1). Besides, the imaging effect of Mn-TCPP-CS20 was superior to that of Gd-DTPA in the same condition. These studies suggested that Mn-TCPP-CS20 has the advantage of becoming a potential tissue-targeting contrast agent.
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YU Dong-jun, LI Min-zhi, HUANG Xian-zhu, ZHU Wei-hua, HUANG Yan, ZHANG Qi, LIU Qing. Preparation of and Study on Magnetic Resonance Imaging Performance of Metal Porphyrin Modified by Low Molecular Weight Chitosan[J]. Spectroscopy and Spectral Analysis, 2013, 33(10): 2736
Received: Jan. 24, 2013
Accepted: --
Published Online: Oct. 23, 2013
The Author Email: Dong-jun YU (ujstrunks@126.com)