A new compression method of interferogram hyperspectral images based on ROI (Region of Interest) coding is proposed,which is based on the analyses of the characteristics of hyperspectral imaging spectrometry. This method that uses the symmetry of the interfering stripes,processes the intra-frame compression and integrates the rectangle ROI coding improves compression ratio of remote sensing images and reaches the requirements of near-lossless compression. Experimental results showed that when relative spectral quadratic error was 2.04% the compression radio reached 9.66∶1.