A spectral-reconfiguration solution based on nonvisual and visual effects is proposed to achieve healthy lighting. A four-channel spectrally reconfigurable calculation model that directly solves the duty cycle of pulse-width modulation according to the circadian-action factor, chromaticity coordinates, and illuminance is established. A remotely controllable and spectrally reconfigurable light-emitting-diode source is designed for experimental verification. The tunability of the circadian-action factor and color-rendering index is discussed, providing theoretical guidance for the selection of relevant parameters. Experimental results show that the relative error between the measured and theoretical values is small. Furthermore, the calculation model can guide spectral reconfiguration on the same chromaticity coordinate, achieving regulation of the circadian-action factor and color-rendering index. Therefore, the computational model can conduct spectral reconfiguration well. This study provides a useful reference for the design of healthy lighting sources for the next generation.