We develop an integrated analysis process on time domain comprising models of disturbances, structures, optical systems, and sampled imaging, and realize the end-to-end system integrated simulation of the space camera from micro-vibration disturbance input to imaging output. Accordingly, a data-transforming toolkit is developed in MATLAB for transferring the structural analysis results to the optical analysis software. The integrated time-domain analysis is carried out in the ground micro-vibration tests of a space camera. The analysis results denote that: under load conditions of two different imaging modes, the maximum statistical values of the dynamic image motions of the camera are 0.42 pixel and 0.27 pixel, respectively; the descending factors of the modulation transfer function of images from the sampled-imaging simulations are 0.951 and 0.974, respectively, which have no obviously visual difference compared with that of original images. These results provide a guidance for the effective prediction of the micro-vibration influence of the space camera.