A correction method for distortion sequences was proposed based on affine transform and multilevel B-spline registration to overcome the image distortion and pixel deviation from the atmospheric turbulence.As the pixel deviation caused by turbulence is nonlinear and random,and the global motion caused by the imaging system movement might exist in practice,the correction method divided the pixel into two parts,the global motion estimation and the local non-rigid registration.The affine transformation was adopted to eliminate the global motion.The multi-resolution strategy was introduced to process pixel distortion and the multilevel B-spline was adopted to register the local motion.On the basis of the symmetry constraint cost function,the control point gridding was fined further to improve the B-spline accuracy by evaluating the regions of interest with the gradient method.Finally,limited-memory Broyden-Fletcher-Glodfarb-Shanno(L-BFGS) algorithm was used to minimize the cost function to obtain the pixel deviation and to complement the correction of image distortion.Experiments demonstrate that the proposed method effectively reduces the pixel distortion from the atmospheric turbulence even for noisy and blurred conditions.