Journal of Innovative Optical Health Sciences, Volume. 16, Issue 3, 2230016(2023)

Deep-learning-based methods for super-resolution fluorescence microscopy

Jianhui Liao1, Junle Qu1, Yongqi Hao2、*, and Jia Li1、**
Author Affiliations
  • 1Shenzhen Key Laboratory of Photonics and Biophotonics, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China
  • 2NARI Group Corporation (State Grid Electric Power Research Institute), NARI Technology Co., Ltd., Nanjing 211106, P. R. China
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    The algorithm used for reconstruction or resolution enhancement is one of the factors affecting the quality of super-resolution images obtained by fluorescence microscopy. Deep-learning-based algorithms have achieved state-of-the-art performance in super-resolution fluorescence microscopy and are becoming increasingly attractive. We firstly introduce commonly-used deep learning models, and then review the latest applications in terms of the network architectures, the training data and the loss functions. Additionally, we discuss the challenges and limits when using deep learning to analyze the fluorescence microscopic data, and suggest ways to improve the reliability and robustness of deep learning applications.

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    Jianhui Liao, Junle Qu, Yongqi Hao, Jia Li. Deep-learning-based methods for super-resolution fluorescence microscopy[J]. Journal of Innovative Optical Health Sciences, 2023, 16(3): 2230016

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    Paper Information

    Category: Research Articles

    Received: Sep. 6, 2022

    Accepted: Oct. 30, 2022

    Published Online: May. 25, 2023

    The Author Email: Hao Yongqi (haoyongqi@sgepri.sgcc.com.cn), Li Jia (jli@szu.edu.cn)

    DOI:10.1142/S1793545822300166

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