To solve the problem of the distribution uniformity and construction rapidity of guide star catalog, a method for guide star selection was proposed, which was based on Polar Coordinates Subdivision Method (PCSM) and “separation-magnitude” weighting method. In order to ensure the distribution uniformity of guide star, the guide star was selected near the reference points on spherical surface neighbourhood, and to insure the results does not overstepp coordinate boundary; by using k-vector method to search candidate stars which was in reference points neighbourhood, the speed of the algorithm could be improved obviously; at last, considering the guide star performance of distribution uniformity and brightness, guide star was selected by “separation-magnitude” weighting method. Simulation results show that the algorithm is simple in realization, and it has strong universality，and the selected guide stars have good uniform distribution.