Although the rock stratum can be blasted into blocks in advance on the ground when the shield machine bores through silt-rock strata, the vibrations generated by blasting in silt-rock strata will threaten the safety of the water supply pipeline near the blast area. Based on the blasting vibrations of field tests and numerical simulations, the physical and mechanical parameters of the materials on sites were verified, and the dynamic response of the water supply pipeline near the blast area was studied. The research results show that the peak particle velocity (PPV) decreases with the increase of the horizontal distance from the explosion source on the pipeline along the axial direction. The PPV also decreases with the increase of the horizontal distance from the explosion source on the ground surface above the pipeline along the axial direction, and there is a relationship between the PPVs of the pipeline and the PPVs of the ground surface above the pipeline. The maximum PPV of the pipeline's inner wall is 3.97 times the minimum PPV, and the PPV is the highest at 90° of the inner wall. Meanwhile, the maximum PPV of the pipeline's outer wall is 1.03 times the minimum PPV, and the PPV is the highest at 150° of the outer wall. Besides, the PPV of each node is different from that of the other, and the PPV on the pipeline's inner wall is more significant than that on the pipeline's outer wall. Although the PPV on the pipeline's inner wall changes significantly, the PPV on the pipeline's outer wall is relatively close. The maximum peak effective stress of the element is 4.06 times the minimum peak effective stress of the element, and the peak effective stress of the element is the highest at 240°~270° of the pipeline's outer wall.