Spectroscopy and Spectral Analysis, Volume. 34, Issue 9, 2587(2014)
Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor
The drug dissolution test is an important examination of drug testing, which plays a very important role in the drug quality assessment. Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology. Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation, with xenon lamp, deuterium lamp or halogen tungsten lamp as fluorescence, UV and visible light source, branch Y type optical fiber as light path transmission medium, UV-Vis probe and fluorescence molecular probe as light response devices, and CCD as detector. Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming, and sampling of off-line analysis, but also provides real-time information of drug dissolution process. Thus, our study may provide a better evaluation method for the drug quality control.
Get Citation
Copy Citation Text
YAO Jun, SHEN Jing, LI Li, LI Xin-xia, CHEN Jian. Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor[J]. Spectroscopy and Spectral Analysis, 2014, 34(9): 2587
Received: Sep. 4, 2013
Accepted: --
Published Online: Sep. 15, 2014
The Author Email: Jun YAO (xydyaojun@163.com)