In order to meet the requirements of piezoelectric ceramics to output a larger range of micro-displacement and maintain higher precision in the vibration platform micro-displacement test system, a high-voltage and high-current piezoelectric ceramic driving power supply with DC-biased continuously frequency-amplitude-modulated sine wave output is designed. The design scheme of the drive power supply, key circuit design, control system software design and experimental test are mainly introduced in this paper. The driving power supply is implemented based on a full-bridge inverter circuit and an isolated DC-DC voltage-raising circuit. The fundamental wave of the voltage-current double-closed-loop proportional-integral-controlled sinusoidal pulse width modulation(SPWM) wave is used to adjust the output voltage. By setting up the experimental platform, it is verified that when the piezoelectric ceramic is 5 μF, the driving power supply can realize 100 times gain amplification in the frequency response of 5 Hz~1 kHz, output 0~1 000 V of dynamic sinusoidal voltage, and 7 kW of maximum output power can be achieved. The results show that the designed piezoelectric ceramic driving power supply has higher output voltage, greater output power, faster frequency response, and reduces the size and weight of the power supply.