Lithium selenoindate (LiInSe2, LISe) crystal has important application in the field of long-wave infrared lasers output. At present, it is still a challenge for the growth of large sized and high quality LISe crystals. The optical quality of crystals are improved by atmosphere annealing post-growth treatment. Large sized (40 mm×60 mm)LISe crystals were grown in batch by the vertical Bridgman method using oriented seed with precise control of seed crystal welding. To the best of our knowledge, it is the largest one for the reported LISe crystals. In addition, the annealing process of LISe crystal was systematically explored, and the results indicate that the optical quality of LISe crystal can be significantly improved by annealing at 740 ℃ for 150 h under LISe intrinsic atmosphere.