Based on the ozone (O3) concentration data of 10 national control stations in Hefei City, China in 2019, the spatial and temporal distribution characteristics of O3 and the influence of meteorological factors were studied by using mathematical statistics and regression analysis. The results show that: (1) the hourly and monthly average concentration of O3 is unimodal, and the monthly average concentration of O3 reaches the peak in June. (2) The contribution rate of O3 in Dongpu reservoir and High Tech Zone to polluted weather is relatively high, and the contribution rate is more than 10%. (3) The stations with more times of exceeding the standard in 2019 are mainly located in Dongpu Reservoir and High Tech Zone, and appear in summer. (4) Temperature, relative humidity and total solar radiation are positively correlated with O3 concentration, and O3 concentration reaches the highest value when temperature is 30～35 °C, relative humidity is 40%～50% and total solar radiation is 800～1000 W·m－2. When the wind speed is 4～4.5 m·s－1, the exogenous transportation is strong and the O3 concentration is high. In addition, precipitation has the scavenging effect on O3 precursor, and the higher O3 concentration, the more obvious the removal effect of precipitation.