Journal of Innovative Optical Health Sciences, Volume. 12, Issue 4, 1930007(2019)

Fast optical wavefront engineering for controlling light propagation in dynamic turbid media

Meiyun Xia1...2, Deyu Li1,2,3, Ling Wang1,2,4,*, and Daifa Wang12 |Show fewer author(s)
Author Affiliations
  • 1School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, P. R. China
  • 2Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, P. R. China
  • 3State Key Laboratory of Virtual Reality Technology and System, Beihang University, Beijing, 100083, P. R. China
  • 4College of Computer Science, Sichuan Normal University, Chengdu, 610101, P. R. China
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    While propagating inside the strongly scattering biological tissue, photons lose their incident directions beyond one transport mean free path (TMFP, ~1 millimeter (mm)), which makes it challenging to achieve optical focusing or clear imaging deep inside tissue. By manipulating many degrees of the incident optical wavefront, the latest optical wavefront engineering (WFE) technology compensates the wavefront distortions caused by the scattering media and thus is toward breaking this physical limit, bringing bright perspective to many applications deep inside tissue, e.g., high resolution functional/molecular imaging, optical excitation (optogenetics) and optical tweezers. However, inside the dynamic turbid media such as the biological tissue, the wavefront distortion is a fast and continuously changing process whose decorrelation rate is on timescales from milliseconds (ms) to microseconds (s), or even faster. This requires that the WFE technology should be capable of beating this rapid process. In this review, we discuss the major challenges faced by the WFE technology due to the fast decorrelation of dynamic turbid media such as living tissue when achieving light focusing/imaging and summarize the research progress achieved to date to overcome these challenges.

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    Meiyun Xia, Deyu Li, Ling Wang, Daifa Wang. Fast optical wavefront engineering for controlling light propagation in dynamic turbid media[J]. Journal of Innovative Optical Health Sciences, 2019, 12(4): 1930007

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    Paper Information

    Received: May. 14, 2019

    Accepted: Jun. 24, 2019

    Published Online: Sep. 3, 2019

    The Author Email: Wang Ling (lingwang@buaa.edu.cn)

    DOI:10.1142/s1793545819300076

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