To undertake analysis of CCD noise effect on lossless compression of remote sensing images, ISO/IEC standard images and UK-DMC multispectral images were selected. The ISO/IEC standard test images were encoded with JPEG2000-lossless compression method after being contaminated with different levels of simulated CCD noise based on CCD noise model. Using the encoded noise image, the change of compression ratios of the images with different noise levels was investigated. Furthermore, the analysis of noise effect on data transmission efficiency was undertaken by using noise-contaminated multispectral images. Based on experimental results, it is indicated that the compression ratio and data transmission efficiency will decrease once the image is contaminated by CCD noise. With regard to CCD noise, the shot and readout noise modeled as Poisson noise and thermal and dark current noise modeled as Gaussian noise are principal factors for the decrease of lossless compression efficiency. The impulse noise induced by detector malfunction has the least effect on the decrease of lossless compression efficiency.