In order to promote the large-scale utilization of phosphogypsum in highway engineering, the comprehensive road performance of phosphogypsum pavement base material was evaluated by typical mechanical test, bubble swelling test, shrinkage test, freeze-thaw cycle test, delayed formation test and low temperature natural curing test. The results show that the mechanical properties of phosphogypsum pavement base material are comparable to those of ordinary cement stabilized crushed stone. The 28 d cumulative expansion rate is only 0.086%, indicating good water stability. The dry shrinkage coefficient is 116.64 με/%, the temperature shrinkage coefficient is 5.15 με/℃, and the compressive strength ratio after freeze-thaw cycles is 81.13%, demonstrating significant shrinkage resistance and frost resistance. Both the delayed formation time and low-temperature curing have adverse effects on the strength of mixture, with a 24% strength decrease after 4 h delay and 33% strength decrease under 5 ℃ curing condition.