The energy coupling of effects of High Power Microwave Weapon (HPMW) on radio fuze is mainly antenna coupling.The induced voltage of high power microwave on fuze antenna was chosen as criterion for the damage simulation model.Parameters of fuze electric components and circuits were also taken into accountwhich could be used for evaluating the destruction effect of the HPMW.The simulation results show that:within height of 1000 metersthe 1 GW coincidence HPMW can achieve the voltage to destroy the receiver and cause radio fuze failure.The result also shows that the method is feasible.